Master's degree in Molecular and Medical Biotechnology

Protein misfolding and human diseases

Course code
Name of lecturers
Paola Dominici, Filippo Favretto
Paola Dominici
Number of ECTS credits allocated
Academic sector
Language of instruction
II semestre dal Mar 1, 2021 al Jun 11, 2021.

Lesson timetable

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Learning outcomes

This course aims to provide information on conformational disease, protein quality control system, chaperone,inherited disorders. In particular, students will gain familiarity with principles of protein misfolding; protein misfolding disease; medical aspects of disease: diagnosis and current therapies


Protein folding and misfolding
Cellular Strategies of Protein Quality Control (PQC)
Molecular chaperones
Structure and Function of the HSP90 machinery
The amyloid state
Tau Proteins
Molecular Pathogenesis of Alzheimer Disease
Techniques for Monitoring Protein Misfolding and Aggregation
Antibodies and protein misfolding
α-Synuclein misfolding and aggregation in Parkinson’s disease
Molecular Pathogenesis in Huntington’s Disease
Superoxide Dismutase in Familial ALS
α1-antitrypsin deficiency
Prions and prionoids
The 26S Proteasome
Targeting the 26S Proteasome
Strategies that target protein aggregation

Assessment methods and criteria

Written test.
The exam consists of 5 open-ended questions on course topics.
The student will choose three out of five questions, he/she will be allowed to answer both in Italian and in English.
The maximum time of the test is two hours

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