Perspectives on Computational Structural/Molecular Systems Biology

Supervisor
Alejandro Giorgetti - Università degli Studi di Verona
Date and time
Tuesday, March 31, 2009 at 4:15 PM - Ore 16.15 caffe' e pasticcini, ore 16.30 inizio seminario
Place
Ca' Vignal - Piramide, Floor 0, Hall Verde
Programme Director
Vincenzo Manca
External reference
Publication date
March 30, 2009
Department
 

Summary

Binding of small molecules to their targets triggers complex pathways. Computational approaches are keys for predictions of the molecular events involved in such cascades. Ultimately, therefore, understanding  of these events, requires the integration of detailed molecular information into the study of biological complexes. In other words, computational systems biology needs to be paralleled by a quantitative description at the molecular level. In this talk I will review current efforts at computationally characterizing the molecular determinants in the largest membrane-bound receptor family, the G-protein-coupled receptors (GPCRs). I will focus on odorant receptors, which constitute more than half GPCRs. The work presented in this seminar uncovers structural and energetic aspects of components of the cellular cascade.






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