Laurea magistrale in Molecular and medical biotechnology

Protein misfolding & human diseases

Codice insegnamento
4S003664
Docente
Paola Dominici
Coordinatore
Paola Dominici
crediti
6
Settore disciplinare
BIO/10 - BIOCHIMICA
Lingua di erogazione
Inglese
Periodo
II semestre dal 4-mar-2019 al 14-giu-2019.

Orario lezioni

Vai all'orario delle lezioni

Obiettivi formativi

Il corso si propone di fornire informazioni su malattie associate a misfolding proteico, sul sistema di controllo della qualità delle proteine, sul ruolo degli chaperones molecolari, e sui disturbi ereditari. In particolare, gli studenti acquisiranno dimestichezza con i principi del misfolding proteico, malattie legate al misfolding delle proteine, aspetti medici delle patololgie: diagnosi e terapie attuali

Programma

PRINCIPLES OF PROTEIN MISFOLDING
Why Proteins Misfold
Endoplasmic Reticulum Stress and Oxidative Stress:
Mechanisms and Link to Disease
Role of Molecular Chaperones in Protein Folding
Kinetic Models for Protein Misfolding and Association
Autophagy: An Alternative Degradation Mechanism
for Misfolded Proteins
Role of Posttranslational Modifications in Amyloid Formation
Protein Misfolding in Alzheimer Disease

PROTEIN MISFOLDING DISEASE: GAIN-OF-FUNCTION AND LOSS-OF-FUNCTION DISEASES
Alzheimer Disease: Protein Misfolding, Model Systems,
and Experimental Therapeutics
Misfolding and Aggregation in Huntington Disease
Systemic Amyloidoses
Copper–Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis
Alpha-1-Antitrypsin Deficiency
Folding Biology of Cystic Fibrosis: A Consortium-Based Approach to Disease
Cataract as a Protein-Aggregation Disease

MEDICAL ASPECTS OF DISEASE: DIAGNOSIS AND CURRENT THERAPIES
Imaging of Misfolded Proteins
Diagnosis of Systemic Amyloid Diseases
Identification of Biomarkers for Diagnosis of Amyloid Diseases
Current and Future Therapies for Alzheimer Disease
Identifying Targets in a-Synuclein Metabolism to Treat
Parkinson Disease and Related Disorders

Modalità d'esame

Written exam on the topics of the course.

The student will choose 3 out of 5 questions and will answer in detail

Opinione studenti frequentanti - 2017/2018






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