Thesis and internship proposals

theses proposal

Structural dynamics, aggregation and interactions of amyloidogenic proteins


Guarantor Michael Assfalg
Suggested date October 1, 2019
Expiry date September 30, 2021
Study courses Master's degree in Molecular and Medical Biotechnology
Description Structural aspects of prototypical amyloidogenic proteins, such as protein Tau (linked to Alzheimer's disease) and alpha-synuclein (associated with Parkinson's disease), aggregation behaviour, conformations, chemical modifications, interactions
Methods:
protein chemistry: cloning, recombinant expression, purification, gel electrophoresis
biophysical techniques (NMR spectroscopy, Circular Dichroism, Dynamic Light scattering, Calorimetry, Atomic force microscopy, Fluorescence spectroscopy)





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