Master's degree in Molecular and Medical Biotechnology

Toxicology and applied pharmacology

Course code
4S003679
Name of lecturer
Anna Benini
Coordinator
Anna Benini
Number of ECTS credits allocated
6
Academic sector
BIO/15 - PHARMACEUTICAL BIOLOGY
Language of instruction
English
Period
I semestre dal Oct 1, 2019 al Jan 31, 2020.

Lesson timetable

Go to lesson schedule

Learning outcomes

The aims of the course are: - introduction to genearal toxicology, mechanisms of action of toxic agents and different classes of drugs
- to study the basic mechanism chracterising toxic effect
- toxic effects of drugs and other chemicals against principals target body organs
At the end students shoul be able to know molecular mechanims of toxic effects, organ toxicity induced by chemicals and/or drugs, toxicity tests.

Syllabus

Introduction to toxicology
Different toxic effects and influencing factors
Toxicokinetics and toxicogenomics
Mechanisms of toxicity
Individual susceptibility to toxic chemicals
Organ toxicity: nervous system, hepatic and renal toxicity, pulmonary and cardiac toxicity, toxicity of immune system, skin toxicity
Nanotoxicology
Computational toxicology
Genotoxicity
Applied pharmacology: drug toxicity and drug interactions
Anti-inflammatory drugs
Cardiovascular medications
Antihypertensive agents
Antiarrhythmic drugs
Anticoagulant drugs
Lipid-lowering agents
Cholinergic and adrenergic drugs
Chemotherapeutics and biotechnological agents

Reference books
Author Title Publisher Year ISBN Note
C.L. Galli, E. Corsini , M. Marinovich Tossicologia Piccin 2016
W. Balduini, L. G. Costa Tossicologia generale e applicata ai farmaci Edra S.p.a. 2015

Assessment methods and criteria

Written examination with 4 open questions on topics of the program.
Each response must have a maximum score of 7.5; the final vote will be given by the sum of the votes of the questions





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