Master's degree in Molecular and Medical Biotechnology

Molecular oncology

Course code
4S003673
Name of lecturer
Vincenzo Corbo
Coordinator
Vincenzo Corbo
Number of ECTS credits allocated
6
Academic sector
MED/08 - PATHOLOGY
Language of instruction
English
Period
I semestre dal Oct 1, 2019 al Jan 31, 2020.

Lesson timetable

Go to lesson schedule

Learning outcomes

This highly interactive course is designed to deliver basic knowledge in molecular oncology as well as innovative experimental approaches to the study of cancer. The specific aim of the class is to provide the student with the means (technological and methodological) to design and execute appropriate experimental approaches to the identification of relevant processes contributing to cancer development and maintenance. For this purpose, the educational format will be based on a series of lessons that will be primarily focused on the description of various aspect of the tumorigenic process, followed by direct interactions based on the students’ presentation of research articles that have changed the oncology field. After attending the class, participants will be able to identify relevant problems related to the field of molecular oncology as well as to distinguish best-fit approaches to solve biological questions. Through the use of journal club the students will also improve their scientific communication skills.

Syllabus

The class will include fontal lessons and discussion with the students of specific research studies using journal club format.
For a total of 24 lessons:
1- The Nature of Cancer
2-Morfological and molecular classification of tumors
3-DNA damage mechanisms
4-Viral and Cellular Oncogenes (part one)
5-Viral and Cellular Oncogenes (part two)
6-Mechanisms of mutagenesis
7-Cancer Models
8-Growth factors and cancer (part one)
9-Growth factors and cancer (part one)
10-Oncosupressors and Knudson' hypothesis
11-P53
12-Cell death (part one)
13-Cell death (part two)
14-Multistep Tumorigenesis
15-Dynamic evolution of cancers
16-Invasion
17-Metastasis
18-Genetic and epigenetic determinants of the Metastases
19-Cancer cell metabolism
20-Metabolic control of epigenetics
21-Journal Club: Genome editing and RNAi
22-Journal Club: Immunotherapy in cancer
23-Journal Club: Stromal cells and cancer
24-Conclusions of the class

Reference books
Author Title Publisher Year ISBN Note
Robert A. Weinberg The Biology of Cancer Garland Science 2014

Assessment methods and criteria

Verification will be a written examination with multiple choice questions covering the whole class and including journal club discussions. No differences are foreseen in the evaluation of students that attended or not the class.





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