Master's degree in Molecular and Medical Biotechnology

Functional proteomics

Course code
Name of lecturer
Alessandra Maria Bossi
Alessandra Maria Bossi
Number of ECTS credits allocated
Academic sector
Language of instruction
I semestre dal Oct 1, 2018 al Jan 31, 2019.

Lesson timetable

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Learning outcomes

The course aims at furnishing the theoretical and technological basis to approach the study of protein functions.
The course integrates proteomic strategies, target identification, biochemical interaction analysis, protein arrays, informatics-based interaction prediction to address the investigation of the proteinogenic changes that underlie the disease pathomechanisms, with examples based on selected diseases.


Characteristics of protein, proteomes and proteomics
Proteomic platforms
Bioinformatic interacting networks
Protein arrays
Imaging SPR
Native MS analysis
Protein enrichment methods
Biochemical approaches to protein protein interaction
Identification of new therapeutic targets in breast cancer
All the supporting material (slides and research papers) will be found on the online platform.

Reference books
Author Title Publisher Year ISBN Note
Peter Atkins, Julio de Paula, James Keeler Physical Chemistry (Edizione 11) Oxford University Press 2018 9780198769866
Wilson, Walker Principles and Techniques of Biochemistry and Molecular Biology Cambridge University Press 2010
Ciborowski P. and Silberring J. Proteomic profiling and analytical chemistry: the crossroads. Elsevier 2013 978-0-444-59378-8

Assessment methods and criteria

The exam aims at evaluating through a 2 hours written test, composed by open questions, the knowledge gained by the student over both the theory and the methodology in the field of functional proteomic investigations.


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